Pyridine and Pyrazine derivative for the Treatment of CF
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United States of America Patent
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Issued Date -
May 15, 2014
app pub date -
Jun 20, 2013
filing date -
Mar 19, 2010
priority date (Note) -
Abandoned
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Abstract
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
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