MONOCLONAL ANTIBODY TO HUMAN EPITHELIAL CELL ADHESION MOLECULE AND METHOD FOR DETECTING CIRCULATING TUMOR CELLS USING THE SAME

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United States of America Patent

APP PUB NO 20140141454A1
SERIAL NO

14085205

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An anti-EpCAM monoclonal antibody is provided which specifically recognizes an epitope different from the epitope which conventionally known anti-EpCAM monoclonal antibodies recognize (the N-terminal EGF-like domain). Also provided is a hybridoma which is capable of producing such monoclonal antibody, and a method for detecting CTC using such monoclonal antibody and a kit for detecting CTC, which is used for the method. The present application provides a monoclonal antibody to the human epithelial cell adhesion molecule (EpCAM) as a solution for the above problem, wherein the monoclonal antibody to the human epithelial cell adhesion molecule (EpCAM) specifically reacts with the CP region of the human epithelial cell adhesion molecule (EpCAM) and is produced by a hybridoma with accession No. NITE BP-1449. There are also provided a method for detecting circulating tumor cells using the above antibody and a kit for detecting circulating tumor cells, which is used for the method, and a hybridoma with accession No. NITE BP-1449.

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Patent Owner(s)

Patent OwnerAddress
NIHON KOHDEN CORPORATION1-31-4 NISHIOCHIAI SHINJUKU-KU TOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nagai, Yutaka Tokyo, JP 127 1737
Takao, Masashi Tokyo, JP 9 16

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