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United States of America Patent

APP PUB NO 20140155275A1
SERIAL NO

14130776

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Abstract

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Assays for detecting mutant sequences at particular locations, especially against a background of non-mutant sequences, employ thermocycling ligase reactions. Differentially labeled or sized probes can be used to distinguish wild-type and mutant sequences. Physico-chemical properties of the probes can be critical to successful detection. Mutation detection can be used for diagnosis, monitoring, or prognosticating diseases such as cancers.

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Patent Owner(s)

Patent OwnerAddress
THE JOHNS HOPKINS UNIVERSITYMARYLAND USA MARYLAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kinzler, Kenneth W Baltimore, US 281 4765
Vogelstein, Bert Baltimore, US 323 6289

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