PYRAZOLYL COMPOUNDS FOR USE IN REVERSING REACTIVE GLIOSIS
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United States of America Patent
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Issued Date -
Jun 12, 2014
app pub date -
May 6, 2011
filing date -
May 6, 2011
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Abstract
The present invention refers to a compound which is a pyrazolyl compound for use as a medicament in a neurodegenerative disease or disorder, preferably reactive gliosis. Also, a pyrazolyl compound that is 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) for use as a medicament in a disease or disorder, preferably for the treatment, reversal or the attenuation of reactive gliosis, and/or reactive gliosis directly or indirectly associated with an eye disease, disease of the retina, or retinal disorder. Further, the invention discloses pharmaceutical compositions thereof and a method for treating a neurodegenerative disorder, preferably reactive gliosis, comprising administering to a subject in need thereof an effective amount of such compound or pharmaceutical composition.
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