Method and apparatus for automated staining of biological materials

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United States of America Patent

PATENT NO 9109984
APP PUB NO 20140178928A1
SERIAL NO

14055528

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Abstract

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Various embodiments of the present invention provide methods and systems for optimally staining biological samples for analysis. In one embodiment, images of a sample are recorded before and after the application of a staining reagent and a decolorization reagent. A difference image is then generated based at least in part on a comparison of the images of the sample recorded before and after the application of the staining and decolorization reagents. Application parameters of the staining and decolorization reagents are then corrected based at least in part on the difference image such that the reagents may be optimally reapplied to generate a final image of the sample that may enable a user to better differentiate at least one target of interest in the sample. In one example, embodiments of the present invention allow for the generation of images that show only Gram-positive bacteria or only Gram-negative bacteria.

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Patent Owner(s)

  • BECTON, DICKINSON AND COMPANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berndt, Klaus W Cockeysville, US 64 2336

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