Mutations in pancreatic neoplasms

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United States of America Patent

PATENT NO 9976184
SERIAL NO

14128478

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Abstract

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To help reveal the pathogenesis of these lesions, we purified the DNA from Intraductal Papillary Mucinous Neoplasm (IPMN) cyst fluids from 19 patients and searched for mutations in 169 genes commonly altered in human cancers. We identified recurrent mutations at codon 201 of GNAS. We found that GNAS mutations were present in 66% of IPMNs and that either KRAS or GNAS mutations could be identified in 96%. In eight cases, we could investigate invasive adenocarcinomas that developed in association with IPMNs containing GNAS mutations. In seven of these eight cases, the GNAS mutations present in the IPMNs were also found in the invasive lesion. GNAS mutations were not found in other types of cystic neoplasms of the pancreas or in invasive adenocarcinomas not associated with IPMNs. These data suggest that GNAS mutations can inform the diagnosis and management of patients with cystic pancreatic lesions.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Diaz, Luis Ellicott City, US 69 462
Hruban, Ralph Baltimore, US 21 49
Kinzler, Kenneth W Baltimore, US 281 4776
Maitra, Anirban Baltimore, US 14 143
Matthaei, Hanno Bonn, DE 2 0
Papadopoulos, Nickolas Towson, US 89 1073
Vogelstein, Bert Baltimore, US 323 6303
Wu, Jian Baltimore, US 381 2215

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