Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels

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United States of America Patent

PATENT NO 9791453
APP PUB NO 20140179540A1
SERIAL NO

13727076

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

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Patent Owner(s)

  • INTERNATIONAL BUSINESS MACHINES CORPORATION;THE UNIVERSITY OF MELBOURNE;FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bathgate, Ross Victoria, AU 5 7
Downton, Matthew Victoria, AU 11 15
Gunn, Natalie Victoria, AU 6 14
Harrer, Stefan Hampton, AU 78 599
Rogers, Priscilla Victoria, AU 4 9
Scott, Daniel Victoria, AU 54 327
Skafidas, Stan Victoria, AU 6 65
Wagner, John North Melbourne, AU 63 1318

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