Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma

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United States of America Patent

PATENT NO 9353418
SERIAL NO

14102730

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We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

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THE JOHNS HOPKINS UNIVERSITY3400 NORTH CHARLES STREET BALTIMORE MD 21205

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Angenendt, Philipp Baltimore, US 10 77
Bigner, Darell Mebane, US 43 327
Jones, Sian Baltimore, US 25 87
Karchin, Rachel Towson, US 11 152
Kinzler, Kenneth W Baltimore, US 281 4771
Kuan, Chien-Tsun Cary, US 32 194
Leary, Rebecca J Baltimore, US 15 247
Lin, Jimmy Cheng-Ho Baltimore, US 13 72
Papadopoulos, Nickolas Towson, US 89 1070
Parmigiani, Giovanni Baltimore, US 14 100
Parsons, D Williams Bellaire, US 18 77
Riggins, Gregory J White Hall, US 20 154
Velculescu, Victor Dayton, US 54 615
Vogelstein, Bert Baltimore, US 323 6299
Yan, Hai Chapel Hill, US 83 895
Zhang, Xiaosong San Francisco, US 43 116

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