Compositions and Methods for the Regulation of T Regulatory Cells Using TL1A-Ig Fusion Protein
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United States of America Patent
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Issued Date -
Jul 10, 2014
app pub date -
Jan 9, 2014
filing date -
Jan 9, 2013
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Abstract
Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also described are combination therapies that include the administration of a TNFRSF25 agonist and an interleukin (e.g., IL-2) and/or an mTOR inhibitor (e.g., rapamycin).
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