MRNA Interferase from Myxococcus Xanthus
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United States of America Patent
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Issued Date -
Jul 10, 2014
app pub date -
Jul 1, 2013
filing date -
Mar 28, 2007
priority date (Note) -
Abandoned
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Abstract
A regulated deployment of a toxin gene for developmental programmed cell death in bacteria is described. M. xanthus is demonstrated to have a solitary mazF gene that lacks a cotranscribed antitoxin gene. Deletion of mazF results in elimination of the obligatory cell death during development causing dramatic reduction in spore formation. Surprisingly, MrpC functions as a MazF antitoxin and a mazF transcription activator. Transcription of mrpC and mazF is negatively regulated via MrpC phosphorylation by a Ser/Thr kinase cascade. Various methods of exploiting this novel pathway are described herein.
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