USE OF PLP WITH PEG-rMETase IN VIVO FOR ENHANCED EFFICACY
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United States of America Patent
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Issued Date -
Jul 24, 2014
app pub date -
Jan 23, 2014
filing date -
Jul 31, 2003
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Abandoned
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Abstract
This invention relates to methods of modifying pyridoxal 5′ phosphate (PLP) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred PLP-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rMETase). The invention further relates to compositions comprising a modified PLP-dependent enzyme and methods of using the same.
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