Methods of Treating TNF-alpha-Mediated Diseases Using Chimeric TNF-alpha Antibodies

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United States of America Patent

SERIAL NO

14158699

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Abstract

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Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

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Patent Owner(s)

Patent OwnerAddress
JANSSEN BIOTECH INC800/850 RIDGEVIEW DRIVE HORSHAM PA 19044

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Daddona, Peter E Menlo Park, US 47 3234
Ghrayeb, John Dowingtown, US 68 2748
Knight, David M Berwyn, US 72 2593
Le, Junming Forest Hills, US 59 2500
Siegel, Scott A Ringoes, US 16 925
Vilcek, Jan T New York, US 13 540

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