PRAME PURIFICATION
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United States of America Patent
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Issued Date -
Aug 21, 2014
app pub date -
Jul 20, 2012
filing date -
Jul 22, 2011
priority date (Note) -
Abandoned
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Abstract
Methods and processes for the purification of PRAME are provided. In particular, methods for reducing the aggregation of PRAME during a diluent exchange from diluent A to diluent B comprising: (i) adding a polyanionic compound to diluent A prior to or contemporaneously with the exchange; and (ii) exchanging protein from diluent A to diluent B are provided. Compositions produced by the method are also provided.
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