SSAT mRNA translation repression and activation

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United States of America Patent

PATENT NO 9585380
SERIAL NO

14342063

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Abstract

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The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase (“SSAT”), wherein translation of an mRNA comprising the encoded SSAT has increased basal translation and increased stimulated translation, compared to a wild-type mRNA encoding SSAT. Methods of use for the nucleic acid are also provided. Methods and compositions are also provided for reducing ischemia-reperfusion injury in organs or tissue for transplantation.

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Patent Owner(s)

Patent OwnerAddress
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION1801 N BROAD STREET STE 401 PHILADELPHIA PA 19122

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abou-Gharbia, Magid Exton, US 19 88
Childers, Wayne E New Hope, US 42 72
Merali, Salim Bryn Mawr, US 14 15
Perez, Leal Oscar Mauricio Barranquilla, CO 3 1

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