Importance

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Abstract

A microfluidic device for separating one or more cells having a diameter and a first surface energy from a bulk fluid having a second surface energy. The microfluidic device has a base portion having a capillary gap with an inlet capillary, an outlet capillary, a bottom surface, a gap height with the ratio of the gap height to the diameter of the one or more cells ranging from 5 to 1 to 100 to 1. The base portion defines a first flow path therethrough, at least one groove formed in the bottom surface of the capillary gap, the at least one groove having a depth, a width, and a third surface energy, and oriented perpendicular relative to the first flow path. The ratio of the groove width to the diameter of the one or more cells ranges from about 5 to 1 to about 100 to 1, and the third surface energy is higher than the first and second surface energies.

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First Claim