Measurement and monitoring of cell clonality

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United States of America Patent

PATENT NO 9068224
APP PUB NO 20140235477A1
SERIAL NO

14148439

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Abstract

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Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boyd, Scott D Stanford, US 7 106
Fire, Andrew Stanford, US 25 2256
Merker, Jason Palo Alto, US 2 64
Osborne, Eleanor M Washington, US 1 3
Seo, Kyunga Daejon, KR 2 64

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