Optically-based stimulation of target cells and modifications thereto

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United States of America Patent

PATENT NO 9458208
APP PUB NO 20140235826A1
SERIAL NO

14184149

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Abstract

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Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berndt, Andre Berlin, DE 10 412
Deisseroth, Karl Standford, US 135 6300
Gunaydin, Lisa San Francisco, US 9 454
Hegemann, Peter Falkensee, DE 18 926
Yizhar, Ofer Rehovot, IL 14 611

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