Peptide linkers for effective multivalent peptide binding

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United States of America Patent

PATENT NO 9278138
APP PUB NO 20140241999A1
SERIAL NO

14191871

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Abstract

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Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.

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Patent Owner(s)

  • E. I. DU PONT DE NEMOURS AND COMPANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Qiong Wilmington, US 83 583
Fahnestock, Stephen R Wilmington, US 45 469
He, Hongxian Wilmington, US 35 373
Kostichka, Kristy N Wilmington, US 10 75
Wang, Hong Kennett Square, US 1090 12499

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