Fermentation Process for the Production of Diphtheria Toxin
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United States of America Patent
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Mar 14, 2014
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Mar 23, 2005
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Abstract
The present invention relates to a fermentation process comprising a fermentation step of growing a strain of Corynebacterium diphtheriae in medium in a fermenter under conditions of agitation sufficient to maintain a homogenous culture and limited aeration such that pO2 within the culture falls to less than 4% for the majority of the fermentation step.
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