METHODS FOR IMPROVING CARDIAC CONTRACTILITY
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United States of America Patent
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Issued Date -
Aug 28, 2014
app pub date -
Dec 17, 2013
filing date -
Dec 18, 2012
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Abstract
The present invention relates to regulation of cardiac contractile function. The present invention is based on the discovery that microRNAs contribute to the loss of cardiac contractility. Specifically, miR-25 binds to SERCA2a which results in a loss of function and interferes with Ca2+ handling. Accordingly, the present invention relates to methods of increasing cardiac contractile function by inhibiting miR-25. The invention further provides methods to identify agents that can modulate miR-25 activity, including high throughput screening methods, and provides a means to identify agents that are useful for treating patients having cardiac contractile function associated disorders.
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