Using RNAi imaging data for gene interaction network construction

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United States of America Patent

PATENT NO 9536042
APP PUB NO 20140270455A1
SERIAL NO

13834742

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Abstract

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Embodiments of the invention relate to a constructing a gene interaction network. Tools are provided to compute a gene relationship measure based upon cellular images, and to rank image collections having a similar morphology. The ranking is based upon capturing similarity within the ranked collection by modeling a three dimensional shape of a cellular image stack. The graph is constructed for related images stacks. Nodes in the graph represent genes, and edges drawn between the nodes represent corresponding image stacks in a commonly ranked list. Accordingly, the graphical representation mathematically and visually connects respective genes.

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Patent Owner(s)

  • INTERNATIONAL BUSINESS MACHINES CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amir, Arnon Saratoga, US 68 2069
Syeda-Mahmood, Tanveer Fathima Cupertino, US 30 647

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