USE OF COELENTERAZINE FOR IMAGING INSULIN-GENERATING BETA-CELLS

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United States of America Patent

APP PUB NO 20140271485A1
SERIAL NO

14210551

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Abstract

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There is a need for a broadly applicable, strain non-specific, bioluminescent imaging tool that will enable researchers to study a β-cell mass in the context of development, disease or transplantation. The disclosure, therefore, encompasses embodiments of a method of identifying a non-diabetic pancreatic β-cell, the method comprising the steps of: delivering to a pancreatic β-cell a composition comprising a coelenterazine; allowing the β-cell to generate a coelenterazine-dependent bioluminescent signal; and identifying the cell as a non-diabetic pancreatic β-cell by detecting the emitted coelenterazine-dependent bioluminescent signal.

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Patent Owner(s)

Patent OwnerAddress
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYOFFICE OF THE GENERAL COUNSEL BLDG 170 THIRD FLOOR MAIN QUAD P O BOX 20386 STANFORD CA 94305-2038

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bronsart, Laura Williams, US 4 0
Contag, Christopher San Jose, US 3 13
Stokes, Christian Minneapolis, US 1 0

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