Mutated anti-TNFα antibodies and methods of their use
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United States of America Patent
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Dec 30, 2014
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app pub date -
Mar 12, 2014
filing date -
Mar 14, 2013
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Abstract
The present invention is directed to modified antibodies, including anti-TNFα antibodies, in which C-terminal amino acids of heavy chain sequences are modified from a native sequence of proline-glycine-lysine (“PGK”) to one that includes a proline positioned between the glycine and lysine, resulting in a C-terminal sequence of proline-glycine-proline-lycine (“PGPK”). The invention further provides methods of producing and using such antibodies.
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