ENHANCED EXPRESSION OF PICORNAVIRUS PROTEINS
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United States of America Patent
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Issued Date -
Sep 18, 2014
app pub date -
Mar 10, 2014
filing date -
Mar 15, 2013
priority date (Note) -
Abandoned
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Abstract
The disclosure provides fusion proteins containing N-terminal signal peptides fused to immunogenic polypeptides. The immunogenic polypeptides may be from viruses, bacteria, or fungi. The disclosure also provides elevated expression of the immunogenic polypeptides using the N-terminal signal peptide. The N-terminal signal peptides enhance synthesis of the protein, particularly where the protein is neither a secretory nor a transmembrane peptide. The fusion proteins may be used to diagnose disease and to induce immune responses.
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