HIERARCHICAL ASSEMBLY OF OPTICAL MAPS
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United States of America Patent
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app pub date -
Mar 14, 2014
filing date -
Mar 15, 2013
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Abandoned
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Abstract
The invention generally relates to optical maps and particularly to computationally tractable methods of assembling large numbers of single molecule maps by dividing the maps into smaller groups of maps within which all of the maps are similar to one another by some metric. For each group, all of the maps are assembled into contigs. The resulting contigs are then assembled into one or more genome assemblies. By dividing the maps into groups, a number of comparison operations required for assembly is reduced and, since each group of maps can be assembled into a contig in a discrete operation, the overall assembly operation can be parallelized.
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