METHODS TO ASSESS ENZYME ACTIVITY USING MASS SPECTROMETRIC IMMUNOASSAY

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United States of America Patent

APP PUB NO 20140273008A1
SERIAL NO

14208519

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Abstract

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Methods to assess biological enzyme activity directly in a complex clinical sample. To such a sample, e.g., plasma, an exogenous synthetic peptide substrate for an enzyme present in the sample and to be assessed is added. The sample then undergoes mass spectrometric immunoassay (MSIA) to monitor the mass spectral profile of the immuno-purified exogenous synthetic peptide substrate directly from the sample. Using the resulting profile, parameters such as enzyme activity and effect of enzyme modulators, including therapeutics administered to an individual for a condition involving the enzyme, may be determined.

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Patent Owner(s)

Patent OwnerAddress
MOLECULAR BIOPRODUCTS INC9389 WAPLES STREET SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kiernan, Urban A Chandler, US 26 67
Niederkofler, Eric E Phoenix, US 12 29

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