Synthetic lariat RNA for RNA interference

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United States of America Patent

PATENT NO 9546364
APP PUB NO 20140273216A1
SERIAL NO

14213164

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Abstract

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Provided herein are compositions for the modification of gene expression by RNA interference using a microRNA (miRNA) guide strand precursor. Methods of making and using the miRNA guide strand precursor also are provided. The compositions bypass the Drosha-Exportin-Dicer pathway and are resistant to nucleases.

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Patent Owner(s)

  • CARNEGIE MELLON UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Das, Subha Ranjan Pittsburgh, US 5 1
Paredes, Eduardo Cincinnati, US 2 0

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