COMPOUNDS AND METHODS RELATING TO LYSOSOMAL STORAGE DISORDERS
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United States of America Patent
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Issued Date -
Sep 18, 2014
app pub date -
Mar 17, 2014
filing date -
Mar 15, 2013
priority date (Note) -
Abandoned
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Abstract
Substrates are provided that include compounds suitable for detecting the activity of an enzyme such as a lysosomal storage enzyme where the substrates include: a sugar moiety; a linker moiety allowing the conjugation of sugar moiety with the remaining structure of the substrate; and two or more fatty acid chains or derivatives thereof at least one of which is sufficiently structured to provide improved solubility in aqueous or organic solvent systems. Also provided are methods for using substrates for detecting enzymatic activity using the inventive substrates.
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