Methods for predictive automatic gain control for hybrid mass spectrometers

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United States of America Patent

PATENT NO 9202681
APP PUB NO 20140306107A1
SERIAL NO

14251137

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Abstract

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A method for mass analyzing ions comprising a restricted range mass-to-charge (m/z) ratios comprising performing a survey mass analysis using a mass analyzer to measure a flux of ions having m/z ratios within said restricted range and performing a dependent mass analysis of an optimal quantity of ions having m/z ratios within said restricted range, said optimal quantity collected for a time period determined by the measured ion flux, CHARACTERIZED IN THAT: the time period is determined using a corrected ion flux that accounts for one or more of: (a) imperfect restriction of collected ions to the range of m/z ratios, (b) inclusion of ions within the range of m/z ratios that are undetected by the survey mass analysis, (c) different mass analyzers used for the dependent and survey mass analyses, and (d) different ion pathways used during dependent and the survey mass analyses.

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Patent Owner(s)

  • THERMO FINNIGAN LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Remes, Philip M San Jose, US 42 106
Senko, Michael W Sunnyvale, US 65 647

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