Antibodies directed against the alpha chain of IL7 receptor—their use for the preparation of drug candidates

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United States of America Patent

PATENT NO 9447182
APP PUB NO 20140308281A1
SERIAL NO

14352992

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Abstract

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The invention concerns antibodies directed against CD127, I.e. the alpha chain of the receptor for interleukin7 (IL-7), especially the receptor for human IL-7 expressed on human cells (designated human IL-7R alpha or IL-7Ra) or the TSLP receptor. The antibodies of the invention have cytotoxic activity against CD127 positive cells. The invention also relates to the use of these antibodies in order to deplete subpopulations of T lymphocytes as a result of cytotoxic action of the antibodies, through ADCC and optionally through CDC. Accordingly the invention concerns the use of the antibodies in the treatment of transplant rejection, autoimmune diseases, allergic diseases, lymphoma or cancer when these pathologies are associated with CD127 positive cells.

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Patent Owner(s)

  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);OSE IMMUNOTHERAPEUTICS

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brouard, Sophie Suce sur Erdre, FR 16 9
Mai, Le Hoa Orvault, FR 1 3
Mary, Caroline Sainte-Pazanne, FR 34 63
Poirier, Nicolas Treillieres, FR 43 75
Soulillou, Jean-Paul Nantes, FR 15 89
Vanhove, Bernard Reze, FR 37 211

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