METAL/SILICA CORE/SHELL NANOPARTICLES, MANUFACTURING PROCESS AND IMMUNOCHROMATOGRAPHIC TEST DEVICE COMPRISING SUCH NANOPARTICLES
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United States of America Patent
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Oct 16, 2014
app pub date -
Nov 5, 2012
filing date -
Nov 15, 2011
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Abstract
A core/shell nanoparticle includes at least one core made from at least one first metallic material based on at least one metal exhibiting plasmon resonance in a domain chosen from ultraviolet, visible and near-infrared, and a silica shell, the silica including functional groups, and on its surface, covalently bonded agents for stabilizing the nanoparticle. A core/shell nanoparticle includes a core made from at least the first material and a metallic shell made from a second different material based on at least one metal exhibiting plasmon resonance in a domain chosen from ultraviolet, visible and near-infrared, the metallic shell being stabilized by a halogen-free surfactant. An immunochromatographic test device for detecting at least one analyte, including binders specific to the analyte, the binders being marked by nanoparticles which include at least one core, made from at least the first material, and a silica shell, the silica including functional groups.
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