Methods for tagging DNA-encoded libraries

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United States of America Patent

PATENT NO 10865409
APP PUB NO 20140315762A1
SERIAL NO

14343306

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Abstract

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The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.

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Patent Owner(s)

Patent OwnerAddress
X-CHEM INC100 BEAVER STREET SUITE 101 WALTHAM MA 02453

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Centrella, Paolo A Acton, US 10 179
Clark, Matthew Lexington, US 64 1206
Cuozzo, John W Natick, US 3 128
Hupp, Christopher D Shrewsbury, US 2 10
Keefe, Anthony D Cambridge, US 19 132
Litovchick, Alexander Sudbury, US 10 65
Wagner, Richard W Cambridge, US 50 1638
Zhang, Ying Lexington, US 923 12176

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