Broadly neutralizing HIV-1 VRC07 antibodies that bind to the CD4-binding site of the envelope protein

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United States of America Patent

PATENT NO 9695230
SERIAL NO

14363740

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Abstract

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Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.

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Patent Owner(s)

  • THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chuang, Gwo-Yu Rockville, US 20 55
Connors, Mark Bethesda, US 27 123
Georgiev, Ivelin Gaithersburg, US 15 31
Kwon, Young Do Rockville, US 63 1036
Kwong, Peter D Washington, US 45 242
Mascola, John Rockville, US 46 79
Nabel, Gary J Cambridge, US 124 3433
Rudicell, Rebecca S Silver Springs, US 6 8
Shi, Wei Rockville, US 226 1412
Wu, Xueling Potomac, US 14 73
Yang, Yongping Potomac, US 29 74
Yang, Zhi-yong Potomac, US 60 448
Zhang, Baoshan Bethesda, US 33 126
Zhou, Tongqing Boyds, US 43 165
Zhu, Jiang Ashburn, US 246 2405

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