THERAPEUTIC PEPTIDES

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United States of America Patent

SERIAL NO

14274735

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Abstract

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Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the E. coli STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising the therapeutic peptides are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
COMBIMAB INC7004 MAPLE AVENUE CHEVY CHASE MD 20815

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ebner, Reinhard Gaithersburg, US 200 1478
Wolfe, Henry Glenmoore, US 26 551

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