Chimeric receptors with 4-1BB stimulatory signaling domain

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United States of America Patent

PATENT NO 9605049
APP PUB NO 20140341869A1
SERIAL NO

14301122

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Abstract

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The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

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Patent Owner(s)

  • ST. JUDE CHILDREN'S RESEARCH HOSPITAL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campana, Dario Singapore, SG 49 968
Imai, Chihaya Niigata, JP 17 774

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