DEXTRAN-BASED TISSUELETTE CONTAINING PLATELET-RICH PLASMA LYSATE FOR CARTILAGE REPAIR
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United States of America Patent
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Nov 20, 2014
app pub date -
Nov 14, 2012
filing date -
Nov 14, 2011
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Abstract
The invention relates to a dextran-based tissuelette comprising platelet-rich plasma lysate (PRPL), which can be used for tissue repair. In particular, the tissuelette of the present invention can be adapted to display properties similar to natural cartilage, while having increased chondrocyte-attraction. Also, it has a tunable biostability that allows for degradation of the tissuelette material during natural tissue regeneration. In addition, the tissuelette displays full and covalent integration with the surrounding tissue when prepared directly at the site requiring tissue repair. The tissuelette of the present invention is primarily meant for use in cartilage repair, in particular cartilage repair upon degradation by osteoarthritis.
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