SYSTEMS AND METHODS FOR PRENATAL GENETIC ANALYSIS
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United States of America Patent
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Nov 20, 2014
app pub date -
Mar 12, 2014
filing date -
Mar 12, 2013
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Abstract
The present disclosure provides for compositions and methods for the testing and analysis of genetic alterations of a sample comprising maternal and fetal polynucleotides. Generally, the composition and methods of this disclosure provide for the isolation of a mixture of maternal and fetal polynucleotides from a sample, generally from the mother. Polynucleotides are isolated and purified and further tested to determine the presence or absence of genetic alterations, such as copy number variation, or causal variants at one or more loci in the sample.
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