METHOD OF MEASURING IMMUNE ACTIVATION
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United States of America Patent
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Issued Date -
Nov 20, 2014
app pub date -
Dec 7, 2012
filing date -
Dec 9, 2011
priority date (Note) -
Abandoned
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Abstract
The invention is directed to methods for measuring immune activation by the level of clonotypes having the same unique regions and different isotype-determining regions. In one aspect, the method of the invention comprises forming a sequence-based clonotype profile from a sample containing B lymphocytes, wherein each clonotype of such profile comprises a unique region, such as a portion of a VDJ segment, and an isotype determining region, such as a portion of a C gene segment. Immune activation is indicated whenever the level of such clonotypes exceeds an upper bound of a reference range determined from multiple individual measurements or population measurements.
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