MODIFIED ADENOVIRAL VECTORS AND METHODS OF TREATMENT USING SAME
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United States of America Patent
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Nov 27, 2014
app pub date -
Sep 7, 2012
filing date -
Sep 9, 2011
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Abstract
The present invention relates to recombinant adenovirus serotype 5 (Ad5) vectors which harbor chimeric capsid proteins including substitutions of the corresponding regions from adenovirus serotypes having a lower seroprevalence relative to Ad5. In particular, the chimeric capsid includes modifications of both the adenoviral hexon and fiber proteins. The invention also provides methods for the treatment of diseases or disorders caused by infective agent(s) by administering the adenoviral vector(s) to a subject (e.g., a mammal, such as a human).
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