High concentration chitosan-nucleic acid polyplex compositions

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United States of America Patent

PATENT NO 9850323
SERIAL NO

14266584

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Abstract

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The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.

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Patent Owner(s)

Patent OwnerAddress
ENGENE INCMONTREAL QUEBEC H4S 1Z9

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheung, Anthony Vancouver, CA 24 151
Fleet, Carlos Vancouver, CA 6 3
Gao, Jun Coquitlam, CA 229 941
Hsu, Eric Vancouver, CA 43 436

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