SEQUENCE-BASED MEASURES OF IMMUNE RESPONSE
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United States of America Patent
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Issued Date -
Dec 4, 2014
app pub date -
Aug 31, 2012
filing date -
Sep 9, 2011
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Abstract
The invention is directed to methods of measuring an immune response by comparing sequence-based clonotype frequency data from successively measured clonotype profiles. In particular, the invention includes immunotherapies of cancers, such as lymphomas, that include sensitive pre- and post-vaccination sequence-based measurements of changes in a patient's immune repertoire, thereby providing a sensitive measure of the likelihood of treatment success.
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