MODULATION OF REPLICATIVE FITNESS BY DEOPTIMIZATION OF SYNONYMOUS CODONS

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United States of America Patent

SERIAL NO

14464619

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Abstract

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Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES CENTERS FOR DISEASE CONTROL AND PREVENTION4770 BUFORD HIGHWAY (K-79) TECHNOLOGY TRANSFER OFFICE ATLANTA GA 30341

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burns, Cara Carthel Avondale Estates, US 7 11
Campagnoli, Raymond Decatur, US 8 36
Kew, Olen M Alpharetta, US 6 29
Quay, Jacqueline Chapel Hill, US 6 29
Shaw, Jing Decatur, US 6 29

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