NOVEL ATTENUATED POLIOVIRUS: PV-1 MONO-CRE-X

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United States of America Patent

APP PUB NO 20140356962A1
SERIAL NO

14365854

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Abstract

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A novel and stable attenuated poliovirus is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region (with inactivation of the native ere element located in the coding region of 2C (mono-crePV), and replacing the nucleic acid sequence of all or part of the capsid coding region (PI) with a substitute PI coding region having reduced codon pair bias. The stably attenuated poliovirus is effective for vaccines and immunization.

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Patent Owner(s)

Patent OwnerAddress
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK35 STATE STREET ALBANY NY 12207

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cello, Jeronimo Port Jefferson, US 8 26
Liu, Ying Port Jefferson, US 607 3685
Wimmer, Eckard East Setauket, US 22 136

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