SYNERGISTIC ANTI-CD47 THERAPY FOR HEMATOLOGIC CANCERS
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United States of America Patent
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Issued Date -
Dec 18, 2014
app pub date -
May 12, 2014
filing date -
Sep 15, 2009
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Abstract
Methods are provided for treatment of hematologic cancers, particularly lymphomas and leukemias, including without limitation myelogenous and lymphocytic leukemias. A combination of antibodies specific for CD47; and specific for a cancer associated cell surface marker are administered to the patient, and provide for a synergistic decrease in cancer cell burden. The combination of antibodies may comprise a plurality of monospecific antibodies, or a bispecific or multispecific antibody. Markers of interest include without limitation, CD20, CD22, CD52, CD33; CD96; CD44; CD123; CD97; CD99; PTHR2; and HAVCR2.
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