Diamino heterocyclic carboxamide compound

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United States of America Patent

PATENT NO 9487491
APP PUB NO 20140371196A1
SERIAL NO

14472959

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EML4-ALK fusion protein, the present inventors found that the diamino heterocyclic carboxamide compounds of the present invention had inhibitory activity against the kinase activity of EML4-ALK fusion protein. By this finding, the present invention was completed. The compounds of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, such as lung cancer, non-small cell lung cancer, and small cell lung cancer.

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Patent Owner(s)

  • ASTELLAS PHARMA INC.;KOTOBUKI PHARMACEUTICAL CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Iikubo, Kazuhiko Chuo-ku, JP 9 184
Iwai, Yoshinori Chuo-ku, JP 11 194
Kamikawa, Akio Chuo-ku, JP 16 185
Kondoh, Yutaka Chuo-ku, JP 26 270
Kurosawa, Kazuo Chuo-ku, JP 10 227
Matsuya, Takahiro Chuo-ku, JP 12 165
Shimada, Itsuro Chuo-ku, JP 19 261
Tomiyama, Hiroshi Chuo-ku, JP 36 779

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