Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
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United States of America Patent
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Jan 15, 2015
app pub date -
Mar 14, 2014
filing date -
Mar 15, 2013
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Abstract
In one aspect, the invention provides an isolated antibody, or antigen-binding fragment thereof, comprising a bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence is an inhibitor of the complement system and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region; or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation.
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