ASSAY AND METHOD FOR IDENTIFYING COMPOUNDS THAT INHIBIT EXCITOTOXIC SIGNALS

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United States of America Patent

APP PUB NO 20150017657A1
SERIAL NO

14365797

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to an assay for identifying compounds for the treatment of various diseases including those associated with excitotoxicity. The invention also relates to cell lines and constructs for use in an assay of the invention. The invention also relates to methods for determining whether a compound reduces excitotoxic signalling in a cell and whether a compound that inhibits binding of Tau to Fyn is likely to selectively reduce excitotoxic cell signalling. The invention also relates to a Tau protein adapted to form a detectable signal when the Tau protein is bound to a Fyn protein. The invention also relates to a Fyn protein adapted to form a detectable signal when the Fyn protein is bound to a Tau protein.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF QUEENSLAND- ST LUCIA QLD 4072 AUSTRALIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Goetz, Juergen Brookfield, AU 10 9
Ittner, Lars Matthias Camperdown, AU 3 0

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