Anti-ADDL monoclonal antibody and uses thereof

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United States of America Patent

PATENT NO 9309309
APP PUB NO 20150023952A1
SERIAL NO

14326974

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Abstract

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The present invention relates to antibodies that bind amyloid β-derived diffusible ligands, also known as ADDLs. The antibodies of the invention are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.

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Patent Owner(s)

  • MERCK SHARP & DOHME CORP.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gaspar, Renee C Souderton, US 6 4
McCampbell, Alexander Chalfont, US 13 4
Shughrue, Paul J West Chester, US 7 4
Wang, Fubao Dresher, US 12 140
Wang, Weirong Harleysville, US 21 356
Xu, Min Ambler, US 262 1831
Zhang, Ningyan Ambler, US 33 50
Zhao, Wei-Qin North Wales, US 14 42

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