Modulation of TIM receptor activity in combination with cytoreductive therapy

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United States of America Patent

PATENT NO 9683049
APP PUB NO 20150023986A1
SERIAL NO

14250250

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Abstract

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A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.

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Patent Owner(s)

  • CHILDREN'S MEDICAL CENTER CORPORATION;DANA-FARBER CANCER INSTITUTE, INC.;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dekruyff, Rosemarie Newton, US 10 131
Freeman, Gordon J Boston, US 87 2311
Jones, Jennifer Palo Alto, US 18 99
Knox, Susan Jane Stanford, US 5 51
Umetsu, Dale T Newton, US 21 394

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