BACTERIAL MEDIATED THF ALPHA GENE SILENCING

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United States of America Patent

SERIAL NO

14064130

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Abstract

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Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating an inflammatory disease or disorder. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.

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Patent Owner(s)

Patent OwnerAddress
BETH ISRAEL DEACONESS MEDICAL CENTERBOSTON MA 02215

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fruehauf, Johannes H Newton, US 5 55
Li, Ching J Cambridge, US 1 13

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